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Sleep and Neuropsychiatric Effects SSRIs exert heterogeneous sleep effects, with fluoxetine and sertraline generally activating sleep, while paroxetine remains sedating and is sometimes leveraged in patients with comorbid insomnia [21,57]

Lower-priced starter doses, subscription-style cash programs and partnerships with digital health platforms are becoming standard

Tirzepatide offers a unique mechanism by impacting both GLP-1 and GIP receptors that help widen its reach beyond mere glucose regulation, providing broader benefits for diabetes management

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Even under conservative assumptions of partial additivity or treatment waning, clinically meaningful benefits persisted