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These findings suggest that nonsteroidal MRAs may offer an additional therapeutic option in HFpEF beyond SGLT2 inhibitors, potentially through anti-inflammatory, antifibrotic, and cardiorenal-metabolic effects

20% of these adults are obese, or 11m people

Although diet interventions in humans are difficult to maintain weight loss, mice respond to caloric restriction (CR) well

The resulting hormonal imbalance can screw with your reproductive cycle, specifically the normal development of egg follicles, and leave you with a bunch of tiny fluid sacs (hence, polycystic)

Sodiumglucose cotransporter 2 inhibitors (SGLT2is) have shown kidney-protective effects in large kidney-dedicated outcome trials [4,5,6], and dedicated kidney outcome trials on glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1ras) are awaited

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