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The cardiovascular biology of glucagon-like Peptide-1

Your doctor may order imaging tests or blood panels to determine whether kidney stones are present and recommend adjustments to your treatment plan

Go Straight to the Manufacturer Pharmaceutical companies like Eli Lilly and Novo Nordisk run their own direct pricing programs (LillyDirect for Zepbound and NovoCare for Wegovy) that allow eligible patients to purchase medication directly

For patients who are not candidates for GLP-1 therapy or who have tried it without success, bupropion-naltrexone is an FDA-approved alternative with a reasonable evidence base

GLP-1RAs directly stimulate POMC/CART neurons and indirectly inhibit NPY and AgRP to increase measures of satiety and decrease hunger, resulting in reduced energy intake, thereby facilitating weight loss (Figure 6)