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White paper Measuring how GLP-1 medications impact the total cost of care Approaches to assessing and managing the effects of GLP-1 drugs on health and financial outcomes Products Related Milliman products Cost-saving analysis Milliman Specialty Pharmacy Insights Identify opportunities to manage specialty pharmacy costs for existing and new drug therapies

In 2025, clinical trials increased by 46%, focusing on combination therapies and improved formulations

OR Induction Dose Option #2 HUMIRA Pen 40 mg/0.4 mL (2) - NDC: 0074-0554-02 X 3 cartons NDC: 0074-0554-02 (2) DAY 1 4 x 40 mg Pen (160 mg) NDC: 0074-0554-02 DAY 15 2 x 40 mg Pen (80 mg) Administer as four 40-mg injections in 1 day or as two 40-mg injections per day for 2 consecutive days

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Less common but more serious side effects of GLP-1 agonists include: pancreatitis, an inflammation of the pancreas that causes abdominal pain gastroparesis, in which movement of food out of the stomach is slowed or stopped bowel obstruction, a blockage that keeps food from passing through the intestines gallstone attacks and bile duct blockage