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Notably, we recently demonstrated that HITI outperforms HDR in terms of knock-in efficacy for GFP gene at the Alb locus in mouse hepatocyte when using clinically relevant, lipid nanoparticle (LNP)-based deliver systems
Psychiatry 12 , 10441060 (2022)
LI-COR Biosciences, Lincoln, NE, USA) for 1 h
Homan J, Betzel B, Aarts EO, van Laarhoven KJ, Janssen IM, Berends FJ
(2018) 7:e009594
Therefore, Mounjaro is expected to have higher efficacy than conventional GLP-1 receptor agonists
