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Description
The mechanism here is multi-factorial: GLP-1R activation reduces hepatic lipogenesis, GIP receptor signalling improves peripheral fat handling, and GCGR activation promotes hepatic fatty acid oxidation directly

however, the exact mechanisms underpinning their utility in these cohorts are poorly understood

A scalable pipeline for local ancestry inference using tens of thousands of reference haplotypes

If your patients would benefit from weight loss alongside their Type 2 diabetes, then using a GLP1 analogue would be a sensible decision and is supported by the new NICE guidelines

Also GLP1RAs have been found to decrease epicardial fat, which may help explain their potential in lowering the risk of atherosclerosis

Remarkably, in recent decades, the understanding of serotonins role in metabolic diseases has greatly increased
