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Notch signaling is a highly conserved cell signaling system in most multicellular organisms and plays a critical role in animal development

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G49, a dual glucagon/glucagon-like peptide-1 receptor agonist, triggers an inter-organ crosstalk between adipose tissue, pancreas and liver, leading to brown fat activation with the final outcomes of increased energy expenditure and body weight loss.

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Na deze opstartperiode wordt de dosering aangepast naar 4 mg voor nog een maand, alvorens naar 9mg eenmaal daags te gaan als onderhoudsdosering