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Reward System Modulation : According to emerging neuroscience research, GLP-1 medications may affect dopamine signaling in the brain's mesolimbic reward pathways, potentially reducing reward-seeking behavior related to highly palatable foods and decreasing emotional eating patterns
According to the Semaglutide Treatment Effect in People with Obesity (STEP) program studies, people with overweight or obesity (without T2DM) who received semaglutide 2.4 mg and underwent lifestyle interventions experienced an average weight reduction of 14.7- 17.4% [116]
At the same time, metabolism can adjust to conserve energy, making it harder to maintain the same rate of weight loss
doi:10.1001/jamainternmed.2022.0338 10
Payers want more and more proof that losing weight reduces the chance of heart disease and diabetes
Guan Z et al
