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[DOI] [PubMed] [Google Scholar] 228.Apovian C.M., et al

In the United States, all GLP-1 medications, such as semaglutide or tirzepatide, require a prescription from a licensed healthcare professional

It affects many different organ tissues in the body, and therefore it is not always immediately obvious that symptoms are histamine driven or mast cell driven

In early January 2024, the FDA investigated several of these medications Ozempic (semaglutide, Novo Nordisk), Wegovy (semaglutide, Novo Nordisk), Saxenda (liraglutide, Novo Nordisk) and two versions of the GIP/GLP-1 dual agonist tirzepatide for suicidal ideation concerns

Patents have grown dense around oral administration, permeation enhancers, and alternative routes including buccal, sublingual, sustained-release depots, and long-duration implants [7, 8, 9, 10]

At NRI, investigators are assessing whether these properties translate into measurable improvements in neurocognitive performance and emotional resilience among individuals undergoing treatment for opioid use disorder