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The primary adverse events reported are gastrointestinal in nature (nausea, vomiting, diarrhea), which is very common for this entire class of medications

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Cost: 20-30% of weight lost comes from muscle

There were some concerns over suicide risk that came up early in the GLP-1 starting era

The MOTS-c side effects profile is relatively mild, though the peptide faces bioavailability and stability challenges that limit its clinical development

By combining GLP-1, GIP, and glucagon receptor agonism, retatrutide addresses not only appetite and insulin but also fat burning, thermogenesis, liver health, and visceral fat