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Our analysis identified a calcium signaling bottleneck as the central explanation for the EVOKE biomarker-clinical disconnect why semaglutide reduced CSF tau and neuroinflammation markers by ~10% yet failed to slow cognitive decline on CDR-SB

Taking a temporary break from semaglutide is medically possible, but the decision depends on your weight loss goals, metabolic changes, and individual response patterns

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No significant differences were observed for myocardial infarction, stroke, or revascularization with risk differences of 0.1% (95% CI 1.0 to 0.8%), 0.8% (95% CI 0.2 to 1.7%), and 0.2% (95% CI -0.71.1%), respectively