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Description
During the first 9 months on the medication, he lost 45 pounds

doi: 10.1007/s00125-005-1878-0

AMPLITUDE-O with efpeglenatide, the latest GLP-1 RA CVOT to report (Gerstein et al., 2021), indeed indicated a benefit on HF, with post hoc analyses showing a significant 39% relative risk reduction on HF requiring hospitalisation (HR 0.61

5A), with a 10% drop in body weight for the highest dose, and an 8% reduction with the 10 and 5 nmol/kg doses relative to vehicle-treated PWA mice (Fig

After stopping, the weight returns

The major source of GLP-1 in the body is the intestinal L cell that secretes GLP-1 as a gut hormone
