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From this group, 139,002 patients were matched in a 1:2 ratio, with 46,334 having been exposed to GLP-1 RAs for at least 6 months and 92,668 serving as unexposed controls

doi: 10.1210/ENDOCR/BQAA246

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Rate and magnitude of weight loss response guide maintenance dose decisions
Among brain areas exhibiting these differences are the PBN and AP/NTS, brain areas implicated as mediators of nausea, nociception, visceral malaise and other responses to aversive stimuli (including reduced food intake) 4851,5161

Why Single-Agent GLP-1 Therapy May Deliver Superior Results Clinical trials demonstrate that semaglutide monotherapy produces sustained weight loss averaging 1015% of baseline body weight over 68 weeks, with continued improvement at higher doses and extended treatment duration
