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7 This is in part caused by its counteracting effect on DPP-4, a GLP-1 inhibitor, prolonging the GLP-1R signal and maintaining insulin secretion

Additionally, in the SELECT trial, adults with obesity and without diabetes receiving semaglutide had a 20% lower risk for major adverse CV events compared with placebo (HR = 0.8

It focuses on the mechanism of action of GLP-1R in pancreatic islet -cells, -cells and -cells, as well as its effects on the central nervous system and gastrointestinal tract

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Healthcare , 9 (4), 402