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A study published in JAMA in January 2025 which looked at more than 125,000 overweight or obese people found that nearly 47% of those with type 2 diabetes and 65% of those without diabetes stopped taking their prescribed GLP-1s within a year of starting them

d PIONEER, 6 was designed to document cardiovascular safety only

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These symptoms are often manageable, particularly when the dose is increased gradually and patients are given practical guidance on meals, hydration, and portion sizes

The hydrogel/medication mix is administered as a small dollop called a depot under the skin in a conveniently out-of-the-way, unbothersome location

The medication can cause side effects such as nausea, constipation, diarrhea, vomiting, indigestion, stomach pain, headache, fatigue, burping, reflux disease, gas and hair loss, the FDA said