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A treatment with DPP-4 inhibitors should be stopped when GLP-1 receptor agonists are used

A small effect on satiety or metabolism is something completely different from a clinically relevant weight loss

March 31st, 2026 5 min read For people whove struggled for years with excessive weight, GLP-1s are a paradigm shift

10.1016/j.tibs.2024.09.007 [DOI] [PMC free article] [PubMed] [Google Scholar] Sharma U., Pal D., Prasad R

PlexusDx Precision Peptide Genetic Test identifies these 14 pathways and 49 peptide markers to guide personalized dose selection that minimizes toxicity risk

The major clinical trials, like the groundbreaking Phase 2 study published in the New England Journal of Medicine, were focused on primary endpoints relevant to its intended therapeutic use: weight reduction, HbA1c levels, lipid profiles, and safety