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increase fiber intake gradually, drink plenty of water, and consider a gentle stool softener if needed

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Safety Considerations When Combining Orlistat With Semaglutide Therapy Clinical data on orlistat combined with GLP-1 agonists remains limited, but no major contraindications have been identified in available literature

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Biochem Biophys Res Commun (2023) 671:20514
This might look like spending six weeks at each dose level instead of four, or inserting an intermediate step at 6mg between the 4mg and 8mg phases
