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7 GLP-1 RA Animal Studies Preclinical animal studies suggest that GLP-1 RAs have the potential to enhance autophagy, protect against mitochondrial stress, boost dopamine production, reduce neuronal loss and terminal denervation, and improve motor function

The evoke and evoke+ trials are currently ongoing to investigate the disease-modifying potential of semaglutide in patients with early-stage symptomatic Alzheimers disease

Among these, parenteral held a significant share of 63.2%

Exenatide weekly, Liraglutide &Dulaglutide have the most reduction effect on HbA1c ( Table 3 ) Table 3: GLP-1RAs summary of head-to-head clinical trials

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