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Weight loss depletes them further

What Should Patients Do

Extended fasting periods may also increase nausea, constipation, or dizziness in patients taking GLP-1 medications, especially during dose escalation phases

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Testing Considerations Depending on symptoms, evaluation may include: SIBO testing Gut microbiome analysis Food sensitivity assessment Histamine evaluation Cortisol rhythm testing Testing should be individualized rather than excessive

In addition, semaglutide therapy modestly, but not significantly, improved MGL from 157.1 21.8 to 143,1 26.4 mg/dL ( p = 0.051), SD from 40.1 6.9 to 35.8 10.1 mg/dL ( p = 0.091) and MODD from 34.0 7.8 to 30.2 9.6 mg/dL ( p = 0.140)