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Health Canada has not yet reviewed or approved Retatrutide for any clinical indication, and approval timelines align with expected FDA decisions in 2026-2027

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However, some patients report cramping, likely due to indirect factors such as electrolyte disturbances or rapid weight loss rather than direct drug effects

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Since weight loss is typically associated with muscle loss, the concern with GLP-1 drugs is whether these medications induce excessive muscle loss than expected for the achieved decline in weight

Additionally, 43.2% of patients on the high dose reported nausea and 33.1% reported diarrhea, compared with 10.7% and 13.4% in the placebo group