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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Kucsera D, Ruppert M, Sayour NV, Tth VE, Kovcs T, Hegeds ZI, et al

In large vessel occlusion (LVO) stroke patients with salvageable penumbra, successful reperfusion by endovascular therapy (EVT) may enable the therapeutic potential of GLP-1RAs to be manifested by: 1) enabling better delivery of the drug and its secondary mediators to vulnerable brain tissues with ischemic injury (even though this is yet to be verified in animal models comparing drug distribution with and without reperfusion under otherwise identical experimental conditions), 2) counteraction of reperfusion injury and neuroinflammation once blood flow is restored, and 3) stabilization of the BBB

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10.1016/j.chom.2023.03.020 57 Reis-BarbosaP