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This hypothesis is further supported by a study [54] which demonstrated that electrical stimulation of afferent renal nerves activates rostral ventrolateral medulla-projecting paraventricular nucleus (PVN) neurons in the hypothalamus

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Follow-up data from the STEP 4 study, published in JAMA in March and also reported by Healio, demonstrated adults with obesity who continued semaglutide 2.4 mg beyond 20 weeks experienced continued weight loss or weight maintenance compared with adults who were switched to placebo

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