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A brief review was conducted to explore current evidence on the interaction between GLP-1RAs and gut microbiotatermed the pharmaco-gut axis. Literature was examined to understand how specific microbial populations affect drug efficacy and insulin sensitivity

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After numerous manipulations on candidate molecules, one was arrived at that acted as a non-peptide GLP-1 agonist and was given the name orforglipron. Now came the next challenge

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