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& Gough, S

Dose selection should weigh both curves

Hence, it remains possible that the lipid-lowering actions of GLP-1 are opposed by increased activity of 1 or more DPP-4 substrates that retain their activity in older mice or after HFD feeding

Multiple high-throughput screening campaigns against class B GPCRs had yielded very few small-molecule hits, and those that did emerge typically showed weak activity or failed to progress beyond early preclinical stages

The goal of a GLP-1 diet is to help you stay satisfied for longer by prioritising foods that digest more slowly and provide steady energy

Diabetes Metab Res Rev (2011) 27(4):36272
