glp-1 receptor agonists effects on cardiovascular risk reduction Impact of outcomes in heart failure with preserved ejection fraction (HFpEF): systematic review and meta-analysis | Clinical Research in Cardiology Effects of GLP-1 receptor agonists

The cornerstone of management is dose titration (start low, go slow)

Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial

doi: 10.3390/antiox11112296 59 WangFSWangWGuSMQiDSmithNAPengWGet al

The amino acid sequence of the GLP-1 protein, though absent in anglerfish, was highly conserved across mammalian species--hinting at its fundamental role in physiology

The resulting increase in vagal toe inhibits gastric emptying and gastric acid secretion, subsequently resulting in a delay of gastric emptying, and reduction of glucose absorption (Shaefer et al, 2015)

Flexible dose adjustment of oral semaglutide led to superior glycemic control and weight loss at week 52 versus sitagliptin and was well tolerated