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We prioritize patient safety and are mindful of specific considerations related to semaglutide, such as its contraindication in individuals with a history of thyroid carcinoma

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Colorado's state employee health plan separately dropped GLP-1 coverage for weight loss in July 2025

The IgG4 Fc region was selected and its sequence modified at several positions to further reduce its interaction with the Fc-y receptors to avoid ADCC immunologic side effects [86]

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