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Compared to WT controls, lymphatics from ApoE KO mice displayed significant contractile dysfunction, which was restored with semaglutide

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an investigational combination therapy being developed by Novo Nordisk that merges two powerful agents: (1) a long-acting amylin analog with a sequence to make it a calcitonin receptor agonist (2) a blockbuster GLP-1 receptor agonist ?via complementary hormonal pathways: mimics the natural hormone amylin, which is co-secreted with insulin