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GLP-1s increased the release of insulin but had an extremely short half-life (one to two minutes), making them highly unfavorable as a treatment for diabetes

January 2024: Multiple Vision Changes Emerge as Potential Concerns for Ozempic A systematic review focused on patients taking semaglutide emerged with multiple primary and secondary outcomes

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doi: 10.2337/diab.43.3.341

Zuraikat FM, Makarem N, Redline S, Aggarwal B, Jelic S, St-Onge MP (2020) Sleep regularity and cardiometabolic heath: is variability in sleep patterns a risk factor for excess adiposity and glycemic dysregulation