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Particular concerns exist for those with: Type 2 diabetes or pre-diabetes , due to opposing and unpredictable glycaemic effects Cardiovascular disease , given the potential for heart rate changes and fluid retention associated with GH Active malignancy , as GH stimulation is contraindicated in this setting Pregnancy or breastfeeding neither agent should be used during pregnancy or whilst breastfeeding

However, these drugs are known to cause a plethora of adverse effects such as weight gain, edema, intestinal discomfort and hypoglycemia (2)

Baggio, L.L

The signal is absent or minimal at lower doses

Cost Considerations : The high cost of brand-name medications can deter patients from seeking treatment