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Many early peptide programs relied on acute or high-dose administration, which produced adverse effects unrelated to therapeutic exposure levels

They believe Eli Lilly could have told Zepbound patients about this risk, but chose not to

"The human GLP-1 analogs liraglutide and semaglutide: absence of histopathological effects on the pancreas in nonhuman primates"

JMCP 29(5):569575 Latif W, Lambrinos KJ, Rodriguez R (2024) Compare and contrast the glucagon-like peptide-1 receptor agonists (GLP1RAs)

I dont want patients to feel like theyre choosing between the good option and the easy option. If a pill fits your life better, that can be a clinical advantagebecause consistency beats perfection