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Many of the common side effects, such as nausea, diarrhea, and vomiting, are most common when starting Mounjaro or increasing the dose

Nutrients (2023)

And because you may lose muscle as well as fat, its more important than ever to strength train to try to keep/build lean muscle massevidence is starting to show that on GLP-1s, strength training and exercise can buffer against muscle loss

Vierteljahresschrift der Naturforschenden Gesellschaft in Zrich

10.3389/fendo.2020.00103

In that study, the glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to initiate a regulatory program driving an early transcriptional activation of metabolic genes, which is followed by a second wave of transcriptional regulation wherein cell-cycle genes are activated and -cell identity genes are repressed