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In the head-to-head SURMOUNT-5 trial, tirzepatide achieved 20.2% mean weight reduction compared to 13.7% with semaglutide at 72 weeksa difference of 6.5 percentage points

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Phase 2: weeks 9 through 20 (ride the wave) This is the acceleration phase

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This is actually beneficial for timing flexibility, because it means your body does not respond to each dose as if it is the first time

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