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Common Questions About GLP1 Medications Are GLP1s safe for long-term use

As an insulinotropic hormone, GLP-1 plays a substantial role in the regulation of glucose homeostasis, not only in the periphery but also in the central nervous system [90]

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This exclusion is significant considering that patients with obesity have a higher risk of developing depression 24

Of note, Covid-19 leads to the induction of fibrotic remodeling secondary to lobar micro-ischemia with the development of fibrotic interstitial changes

This creates a metabolic environment where weight loss becomes exceptionally difficult and fat storage, particularly visceral fat around the abdomen, becomes the default