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Conclusions Using GLP-1RAs versus insulin for type 2 diabetes patients requiring intensified injection therapy in clinical practice is cost-effective.

GLP-1 Agonists are a growing class of medications use for diabetes

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Tirzepatide works by increasing insulin secretion, reducing glucagon (a hormone that raises blood sugar), and slowing down the emptying of food from the stomach, which helps to lower blood sugar levels after a meal

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If the SOUL study corroborates the findings of this model, it may not only form the basis for the calculation of power but also define the duration of such studies, reducing costs and easing the process of designing cardiovascular outcome trials (CVOTs)