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Clinical studies have shown that patients using these medications can experience significant weight reduction, especially when combined with lifestyle changes such as a healthy diet and increased physical activity

empagliflozin in particular reduces hospital admission with heart failure

Liraglutide: Average reduction of 1.0-1.3 percentage points

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The STEP1 and SURMOUNT trials demonstrated sustained clinically relevant reduction in body weight with semaglutide and tripeptide, respectively, in patients with overweight and obesity

Patients with certain genetic variants may respond more strongly to semaglutide monotherapy, while others benefit from dual-pathway activation using tirzepatide or GLP-Squared combinations