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Bitter melon is a traditional and natural fruit whose extracts and compounds, such as charatin and vicine, are often used in supplement form to promote weight loss

After 28 days, the risk of bacterial growth increases, even if the medication itself is still chemically stable

Semaglutide is a validated pharmaceutical for metabolic disease

These agents have been supported by important clinical trials, including Satiety and Clinical Adipose Liraglutide Evidence (SCALE), Semaglutide Treatment Effect in People with Obesity (STEP) program trials, and Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) (44)

The primary endpoint was the time from randomization to the first occurrence of a MACE, a composite of death from CV causes (including undetermined causes of death), nonfatal myocardial infarction, or nonfatal stroke [44]

The mean (SD) days covered with a 1.0 mg maintenance dose was 236.1 (94.1) days ( Table 2 )