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16S rDNA sequencing and deep-sequencing shotgun metagenomics was applied for comprehensive within-subject profiling of changes in gut microbiome signatures

The ADAs 2026 update discusses GLP-1 RA effects on eye health including potential impacts on diabetic retinopathy progression, glaucoma, and macular degeneration

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when cardiac cytoplasmic Na + and Ca 2+ concentrations and mitochondrial Ca 2+ were measured fluorometrically in isolated ventricular myocytes from rabbits and rats, the results evidenced that empagliflozin directly inhibited NHE flux, caused by a reduction in cytoplasmic Na+ and Ca 2+ concentrations and an increase in mitochondrial Ca 2 [118]

The withdrawal of approval of rosiglitazone due to the increased risk of cardiovascular events [20] resulted in a demand for studies demonstrating cardiovascular safety for any new antidiabetic drug
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