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The spinal axis bypasses all three, directly interacting with ependymal cells, astrocytic networks, and dorsal root ganglia (DRG) nodes governing pain, mood, and neuroimmune crosstalk

579.Adler AI, Stratton IM, Neil HA, et al Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS36): prospective observational study

In contrast, the pharmacological nanomolar concentrations of GLP-1RAs predominantly activate the cAMP/PKA pathway, potentially explaining their broader therapeutic effects [122]

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