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Semaglutide Improved Reserpine-induced Depressive Behavior and Motor-incoordination in Rats Reserpine administration for three days (day 0) remarkably precipitated depressive-like symptoms and produced negative effect on motor functions as witnessed in forced swimming and rotarod tests during the tested four-points interval

Previous studies show that administration of GLP-1 analogues, including exenatide (exendin-4), dulaglutide, and liraglutide in mice, rats, and nonhuman primates, suppressed outcomes related to alcohol reward, including alcohol-induced dopamine release in the nucleus accumbens, conditioned place preference for alcohol, and alcohol self-administration (6, 17)

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Histological assessment and scoring were performed by a pathologist blinded to the study

Gelling, R

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