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Others may require higher doses but face tolerability issues like nausea, vomiting, or gastrointestinal distress that prevent reaching therapeutic levels

Furthermore, oral formulations may enhance convenience, acceptance, and adherence to GLP-1RA therapy, offering an alternative to facilitate the attainment of glycemic targets, especially in patients hesitant to commence injectable medications [49]

Research Insights Despite semaglutides proven efficacy in diabetes and obesity treatment, there is significant heterogeneity in weight loss experienced by patients and genetic factors remain unclear

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Recent 2024 multi-society guidance from the American Society of Anesthesiologists (ASA) provides a risk-stratified approach to perioperative management