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After 45 minutes, they feel almost nothing

Therefore, there is no clinically relevant effect of renal impairment on TZT pharmacokinetics, and dose adjustment is not required for patients with renal impairment

Skrha et al

Prog Biophys Mol Biol 107: 236-247, 2011

An independent licensed provider must review the patient's intake and determine that treatment is clinically appropriate before a prescription is issued

If nausea persists during dose increases, your healthcare provider might adjust your plan by extending the current dose for an additional 2-4 weeks, pausing further increases until symptoms improve, or temporarily lowering the dose