glp-1 craze Julia Belluz on GLP1RAs and even the Reta craze, in the NYT, with quotes from Dan Drucker https://www.nytimes.com/interactive/2026/04/15/opinion/glp1 -health-effects.html?unlocked_article_code=1.cFA.rAv8.ZG65fhDRLLjJ&smid=nytcore-ios-share GiftLink GLP-1s are the current craze

The closed conformation of the peptide-free GLP-1R compared to GCGR is quite divergent in the extracellular region and may be a consequence of sequence diversity, which is important for understanding the signalling pathway for different receptors within the class B family

Those experiencing gastrointestinal side effects may benefit from oral rehydration solutions or electrolyte-containing beverages

For example, semaglutide induces weight losses greater than 15% in 60% of those treated, and nearly 40% even lost more than 20% of their initial body weight (Figure 6A)

compounded semaglutide via 503A telehealth ($99 to $249)

Its that simple. See the FDA's warning on compounded GLP-1s here

This hormone has multiple mechanisms of action, all potentially useful in the treatment of diabetes as well as weight loss