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Phase 2 data published in The New England Journal of Medicine in 2023 suggest meaningful weight reductions can begin within the first few months of treatment, with results continuing to build over 48 weeks

Clinical trials have demonstrated that GLP-1 receptor agonists produce substantial reductions in total body weight, with emerging evidence suggesting effects on visceral adipose tissuethe metabolically active fat stored around abdominal organs

This individualized strategy can maximize reductions in albuminuria and slow CKD progression, while minimizing adverse effects [16,17]

Collectively, these findings suggest that tirzepatide may affect OSAS severity predominantly through metabolic and inflammatory improvement, with potential adjunctive neuromuscular contributions

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