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It does not mean the compound "stopped working." It means it is clearing your system as intended

recently analysed a cohort of 3737 patients with IBD and T2DM, demonstrating that the use of GLP-1RAs was associated with a 26% reduction in the risk of composite IBD outcomes, defined as steroid dependence, the initiation of advanced IBD therapy, hospitalization, surgery, or death (aHR: 0.74, 95% CI: 0.620.89) [32]

Retrieved from Pansari, A., Pan, X., Almond, L

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Hamilton GS et al

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