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10.1038/s41598-020-59314-7 Sci

combining GLP-1 agents increases risk of gastrointestinal side effects and hypoglycemia if diabetes medications are also present

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"It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30% of their body weight over two years

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Approximately 2429% average weight reduction