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C.ColhounH

The once-effortless balance between calories in and calories out is suddenly disrupted: weight gain gathers around the abdomen, cholesterol climbs, insulin sensitivity declines, and hot flashes arrive as an unwelcome guest

N., Savage, M
Among the numerous major discoveries made in this regard was the finding that the hyperglycemic effect of glucagon resides in its ability to act in the liver to stimulate glycogenolysis and gluconeogenesis [[6], [7], [8], [9], [10], [11], [12]] despite its seemingly paradoxical ability to stimulate insulin secretion in humans reported by Ellis Samols in 1965 [13]
5), consistent with the results reported in cultured hippocampal neurons showing that acute application of GLP-1 induces a transient elevation of [Ca 2+ ] i [58]

10.1136/gut.2004.059741 132
