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First, GLP-1RA can activate the first messenger adenylate cyclase (AC) after binding to the receptor, which stimulates an increase in the secretion level of the intracellular second messenger cyclic adenosine phosphate (cAMP) and subsequently activates the intracellular secondary messenger protein kinase A (PKA) (48)

These drugs are also known as GLP-1 agonists and are now commonly used as type 2 diabetes medication

Ozempic can lower the risk of worsening kidney disease in adults with type 2 diabetes and chronic kidney disease

doi: 10.1016/S0140-6736(14)61601-9

(2011) 34 Suppl 2:S2517

There is a causal relationship between hyperinsulinemia and pancreatic cancer events under an inflammatory environment (Gao et al., 2015)