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For instance, a study found that semaglutide modulates central GABA neurotransmission, which is implicated in alcohol withdrawal and craving [45]

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Martchenko SE, Martchenko A, Biancolin AD, Waller A, Brubaker PL

That effect, he says, may be tied to changes in the brains reward system

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therefore, while muscle mass goes down on scans, patients may be getting stronger, more mobile, and more physically capable