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Available as Ozempic (for type 2 diabetes), Wegovy (for weight management), and Rybelsus (oral tablet for diabetes), semaglutide targets the GLP-1 receptor exclusively

With the successive launch of Glucagon-like peptide-1 (GLP-1) class drugs that allow weight loss with a once-daily pill instead of an injection, the barrier to obesity treatment is lowering

The OR for achieving a weight loss of at least 5% with tirzepatide 5 mg, 10 mg and 15 mg (vs GLP-1 RAs) was, respectively, 1.96 (95% CI 1.01, 3.80 [ I 2 61%]), 4.79 (95% CI 1.95, 11.73 [ I 2 74%]) and 4.57 (95% CI 3.38, 6.18 [ I 2 0%]) (ESM Table 2)

All these medications carry risks of uncommon but serious adverse effects, including pancreatitis and gallbladder disease

Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial