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13 This difference may be due to inadequate power in our study since we had LDL data in only a subset of subjects

Weight reduction in this subgroup was dose-proportional but numerically lower than in the overall population

Topical treatments : For localized joint pain, particularly in osteoarthritis, topical NSAIDs such as diclofenac gel can provide relief with fewer systemic side effects than oral medications

The safety and efficacy of this specific combination have not been directly evaluated by the FDA

The TCF7L2 rs7903146 T allele, a known T2DM risk variant, alters -cell incretin sensitivity and impacts the response to GLP-1 receptor agonists [89]

A 1,000 mcg sublingual B12 supplement or a tirzepatide formulation with B12 addresses this concern